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p auroraa t288 b t232 c t198 r v cst 2914 rabbit auroraa aik r v cst 3092 rabbit  (Cell Signaling Technology Inc)


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    Cell Signaling Technology Inc p auroraa t288 b t232 c t198 r v cst 2914 rabbit auroraa aik r v cst 3092 rabbit
    P Auroraa T288 B T232 C T198 R V Cst 2914 Rabbit Auroraa Aik R V Cst 3092 Rabbit, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 596 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/phospho+auroraa+t288/Phospho-ATR+(Ser428)+Antibody/10__1523_slash_eneuro__0272___17__2017-127-67-68
    Average 96 stars, based on 596 article reviews
    p auroraa t288 b t232 c t198 r v cst 2914 rabbit auroraa aik r v cst 3092 rabbit - by Bioz Stars, 2026-10
    96/100 stars

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    Article Title: Chemogenetic Evaluation of the Mitotic Kinesin CENP-E Reveals a Critical Role in Triple-Negative Breast Cancer
    Article Snippet: Breast cancer patients with tumors lacking the three diagnosticmarkers (ER, PR, andHER2) are classified as triple-negative (primarily basal-like) and have poor prognosis because there is no disease-specific therapy available.. To address this unmet medical need, gene expression analyses using more than a thousand breast cancer samples were conducted, which identified elevated centromere protein E (CENP-E) expression in the basal-a molecular subtype relative to other subtypes.. CENP-E, a mitotic kinesin component of the spindle assembly checkpoint, is shown to be induced in basal-a tumor cell lines by the mitotic spindle inhibitor drug docetaxel.

    Article Title: Chemogenetic Evaluation of the Mitotic Kinesin CENP-E Reveals a Critical Role in Triple-Negative Breast Cancer
    Article Snippet: Lysates (with protease and phosphatase inhibitors added) were resolved by NUPAGE gels (Invitrogen), transferred to nitrocellulose membranes, and probed using antibodies for actin and cyclin B (Santa Cruz Biotechnology Inc.), AuroraB/AIM1, phospho-AuroraA(T288)/B(T232)/C(T198; Cell Signaling Technology; cat. #2914; 1:500 dilution), phosphoHH3-Ser10, cleaved PARP (all from Cell Signaling Technology;), anti-phosphohistone-H2AX Ser139 (Millipore), securin (Abcam), anti-BubR1 (Bethyl Laboratories, Inc.), and 1:500 dilution anti-CENP-E (cat. #AKIN04-A, Cytoskeleton Inc.) overnight at 4 C. HRP-conjugated secondary antibodies (GE Healthcare) were incubated (2 hours, room temperature), detected using a chemiluminescent substrate (Pierce SuperSignal West Dura; Thermo Fisher Scientific), and imaged (Alpha Innotech imager; Cell Biosciences).



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